SCREENING OF MULTI-COMPONENT PROTEIN SYSTEMS
III. Neugenesis' heterokaryon library platform permits generation of ordered cell culture arrays using variants of multi-component gene and/or protein systems. This allows the user to screen for novel combinations of biological material with commercially desirable properties.
The following sets of cartoons illustrate this third technology platform. In these illustrations, recombinant immunoglobulins (IgGs) are used as an example, but the technology is broadly applicable to a wide range of multimeric proteins.
US Patent 5,643,745 |
Heterologous Dimeric Proteins Produced in Heterokaryons |
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Just as one fused culture produces one multimeric molecule, multiple fused heterokaryotic cells can be used to produce panels of cell cultures where each individual culture produces a unique multimeric molecule.
US Patent 5,683,899 |
Methods and Composition for Combinatorial Based Discovery of New Multimeric Molecules |
Allowed
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By transforming host cells with blocks of genomic DNA from two non-Neurospora species, multiple fused heterokaryotic cell cultures can be made into panels of cell cultures, each with a potentially new metabolic pathway for proteins or secondary metabolites.
Patent Pending |
Combinatorial Metabolic Libraries |
